KB-5492 free base

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

KB-5492 free base 是一种有效的和选择性的 sigma 受体抑制剂，抑制 [3H]1,3-di(2-tolyl)guanidine (DTG) 与 sigma 受体结合，IC50 值为 3.15 μM。KB-5492 free base 是一种抗溃疡剂。

KB-5492 free base is a potent and selective inhibitor of sigma receptor, inhibits specific [3H]1,3-di(2-tolyl)guanidine (DTG) binding to the sigma receptor with an IC50 of 3.15 μM. KB-5492 free base is an anti-ulcer agent.

KB-5492 (0.001-100 μM) free base inhibits specific [3H]DTG binding in a concentration-dependent manner.KB-5492 (0.1-1 mM) free base significantly and concentration-dependently prevents the ethanol- and acidified aspirin-induced increases in 51Cr release from gastric epithelial cells.

KB-5492 (200?mg/kg; p.o.) free base prevents macroscopic lesions in the gastric mucosa.Animal Model:Male Sprague-Dawley rats weighing 210-240 g are induced gastric mucosal damage Dosage:200?mg/kg Administration:Oral gavage Result:Reduced the lesion length as compared with the control.Prevented the deep mucosal lesions and exfoliation of surface epithelial cells.

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Autophagy

Sigma receptor

Sigma receptor

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113594-64-2

430.49

C23H30N2O6

>98% (HPLC)

In Vitro:?DMSO 中的溶解度 : 100 mg/mL (232.29 mM; 超声助溶 )

COc1ccc(OC(=O)CN2CCN(Cc3cc(OC)c(OC)c(OC)c3)CC2)cc1

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(-20℃)

With Ice Pack

≥ 2 years